by author Publications by date


  • Bubier JA, Sutphin GL, Reynolds TJ, Korstanje R, Fuksman-Kumpa A, Baker EJ, Langston MA, Chesler EJ
    Integration of heterogeneous functional genomics data in gerontology research to find genes and pathway underlying aging across species
    PLoS One. 2019 Apr 12;14(4):e0214523. doi: 10.1371/journal.pone.0214523 PMID: PMC6461221
  • Alghamdi SM, Sundberg BA, Sundberg JP, Schofield PN, Hoehndorf R.
    Quantitative evaluation of Ontology design patterns for combining pathology and anatomy ontologies
    Sci Rep. 2019 Mar 11;9(1):4025. doi:10.1038/s41598-019-40368-1. PMID: 30858527
  • Loberg MA, Bell RK, Goodwin LO, Eudy E, Miles LA, SanMiguel JM, Young K, Bergstrom DE, Levine RL, Schneider RK, Trowbridge JJ.
    Sequencially inducible mouse models reveal that Npm1 mutation causes malignant transformation of Dnmt3a-mutant clonal hematopoiesis
    Leukemia. 2019 Jan 28. doi: 10.1038/s41375-018-0368-6. [Epub ahead of print]


  • Thompson MJ, Chwiałkowska K, Rubbi L, Lusis AJ, Davis RC, Srivastava A, Korstanje R, Churchill GA, Horvath S, Pellegrini M
    A Multi-tissue full lifespan epigenetic clock for mice
    Aging (Albany NY). 2018 Oct 21;10(10):2832-2854. doi: 10.18632/aging.101590. PMID:30348905
  • Backer G, Eddy S, Sheehan SM, Takemon Y, Reznichenko A, Savage HS, Kretzler M, Kostanje R
    FAR2 is Associated with Kidney Disease in Mice and Humans
    Physiologenomics. 2018 Apr 13 doi:1152/physiolgenomics.00118.2017


  • Lee BP, Curic I, George-Pandeth A, Flurkey K, Harrison DE, Yan R, Peters LL, Kuchel GA, Melzer D, Harries LW
    MicroRNAs miR-203-3p, miR-664-3p and miR-708-5p are associated with median strain lifespan in mice
    Sci Rep. 2017 Mar 17;7:44620. doi: 10.1038/srep44620
  • Sutphin GL, Backer G, Sheehan S, Bean S, Corban C, Liu T, Peters MJ, van Merus JBJ, Murabito JM, Johnson AD, Korstanje R, Cohorts for Heart & Aging Research in Genomic Epidemiology Consortium Gene Expression Working Group
    Caenorhabditis elegans orthologs of human genes differentially expressed with age are enriched for determinants of longevity
    Aging Cell, 2017 Aug;16(4):672-682. doi: 10.1111/acel.12595.
  • Tyler AL, Ji B, Gatti DM, Munger SC, Churchill GA, Svenson KL, Carter GW
    Epistatic Networks Jointly Influence Phenotypes Related to Metabolic Disease and Gene Expression in Diversity Outbred Mice
    Genetics. 2017 Jun;206(2):621-639. doi: 10.1534/genetics.116.198051


  • Bogue MA, Peters LL, Paigen B, Korstanje R, Yuan R, Ackert-Bicknell C, Grubb SC, Churchill GA, Chesler EJ
    Accessing Data Resources in the Mouse Phenome Database for Genetic Analysis of Murine Life Span and Health Span
    J Gerontol A Biol Sci Med Sci. 2016 Feb;71(2):170-7. doi: 10.1093/gerona/glu223

    [ Epub 2014 Dec 22 ]

  • Korstanje R, Deutsch K, Balanos-Palmieri P, Hanke N, Schroder, P, Staggs L, Brasen JH, Roberts IS, Sheehan S, Savage H, Haller H, Schiffer M
    Loss of Kynurenine 3-Mono-oxygenase Causes Proteinuria
    J Am Soc Nephrol. 2016 Nov;27(11):3271-3277
  • Lee BP, Pilling LC, Emond F, Flurkey K, Harrison DE, Yuan R, Peters LL, Kuchel GA, Ferrucci L, Melzer D, Harries LW
    Changes in the expression of splicing factor transcripts and variations in alternative splicing are associated with lifespan in mice and humans
    Aging Cell. 2016 Jun 30. doi: 10.1111/acel.12499

    [Epub ahead of print]

  • Sutphin GL, Mahoney JM, Sheppard K, Walton DO, Korstanje R
    WORMHOLE: Novel Least Diverged Ortholog Prediction through Machine Learning
    PLoS Comput Biol. 2016 Nov 3;12(11):e1005182. doi: 10.1371/journal.pcbi.1005182.
  • Young K, Borikar S, Bell R, Kuffler L, Phillip V, Trowbridge JJ
    Progressive alterations in multipotent hematopoietic progenitors underlie lymphoid cell loss in aging
    J Exp Med. 2016 Oct 17;213(11):2259-2267. Epub 2016 Oct 10.


  • Ackert-Bicknell CL, Anderson LC, Sheehan S, Hill WG, Chang B, Churchill GA, Chesler EJ, Korstanje R, Peters LL
    Aging Research Using Mouse Models
    Curr Protoc Mouse Biol. 2015 Jun 1;5(2):95-133. doi: 10.1002/9780470942390.mo140195
  • Aziz MH, Chen X, Zhang Q, DeFrain C, Osland J, Luo Y, Shi X, Yuan R
    Suppressing NRIP1 inhibits growth of breast cancer cells in vitro and in vivo
    Oncotarget. 2015 Nov 24;6(37):39714-24. doi: 10.18632/oncotarget.5356
  • Bogue MA, Churchill GA, Chesler EJ
    Collaborative Cross and Diversity Outbred data resources in the Mouse Phenome Database
    Mamm Genome. 2015 Oct;26(9-10):511-20. doi: 10.1007/s00335-015-9595-6

    [ Epub 2015 Aug 19 ]

  • Noordmans GA, Hillebrands JL, van Goor H, Korstanje R
    A roadmap for the genetic analysis of renal aging
    Aging Cell. 2015 Oct;14(5):725-33. doi: 10.1111/acel.12378

    [ Epub 2015 Jul 29 ]

  • Reznichenko A, Korstanje R
    The role of platelet-activating factor in mesangial pathophysiology
    Am J Pathol. 2015 Apr;185(4):888-96. doi: 10.1016/j.ajpath.2014.11.025

    [ Epub 2015 Feb 2 ]

  • Yuan R, Gatti DM, Krier R, Malay E, Schultz D, Peters LL, Churchill GA, Harrison DE, Paigen B
    Genetic Regulation of Female Sexual Maturation and Longevity Through Circulating IGF1
    J Gerontol A Biol Sci Med Sci. 2015 Jul;70(7):817-26. doi: 10.1093/gerona/glu114

    [ Epub 2014 Jul 28 ]


  • Gatti DM, Svenson KL, Shabalin A, Wu LY, Valdar W, Simecek P, Goodwin N, Cheng R, Pomp D, Palmer A, Chesler EJ, Broman KW, Churchill GA
    Quantitative trait locus mapping methods for diversity outbred mice
    G3 (Bethesda). 2014 Sep 18;4(9):1623-33. doi: 10.1534/g3.114.013748
  • Gokhin DS, Dubuc EA, Lian KQ, Peters LL, Fowler VM
    Alterations in thin filament length during postnatal skeletal muscle development and aging in mice
    Front Physiol. 2014 Sep 29;5:375. doi: 10.3389/fphys.2014.00375

    [ eCollection 2014 ]

  • Grubb SC, Bult CJ, Bogue MA
    Mouse phenome database
    Nucleic Acids Res. 2014 Jan;42(Database issue):D825-34. doi: 10.1093/nar/gkt1159

    [ Epub 2013 Nov 15 ]

  • Huang Y, Caputo CR, Noordmans GA, Yazdani S, Monteiro LH, van den Born J, van Goor H, Heeringa P, Korstanje R, Hillebrands JL
    Identification of novel genes associated with renal tertiary lymphoid organ formation in aging mice
    PLoS One. 2014 Mar 17;9(3):e91850. doi: 10.1371/journal.pone.0091850

    [ eCollection 2014 ]

  • Moeller M, Hirose M, Mueller S, Roolf C, Baltrusch S, Ibrahim S, Junghanss C, Wolkenhauer O, Jaster R, Köhling R, Kunz M, Tiedge M, Schofield PN, Fuellen G
    Inbred mouse strains reveal biomarkers that are pro-longevity, antilongevity or role switching
    Aging Cell. 2014 Aug;13(4):729-38. doi: 10.1111/acel.12226

    [ Epub 2014 May 23 ]

  • Mostafavi S, Ortiz-Lopez A, Bogue MA, Hattori K, Pop C, Koller D, Mathis D, Benoist C;
    Variation and genetic control of gene expression in primary immunocytes across inbred mouse strains
    Immunological Genome Consortium. J Immunol. 2014 Nov 1;193(9):4485-96. doi: 10.4049/jimmunol.1401280

    [ Epub 2014 Sep 29 ]

  • Noordmans GA, Huang Y, Savage H, van Dijk MC, Schaart G, van den Bergh Weerman MA, Heeringa P, Hillebrands JL, Korstanje R, van Goor H
    Genetic analysis of intracapillary glomerular lipoprotein deposits in aging mice
    PLoS One. 2014 Oct 29;9(10):e111308. doi: 10.1371/journal.pone.0111308
  • Yu W, Ackert-Bicknell C, Larigakis JD, MacIver B, Steers WD, Churchill GA, Hill WG, Zeidel ML
    Spontaneous voiding by mice reveals strain-specific lower urinary tract function to be a quantitative genetic trait
    Am J Physiol Renal Physiol. 2014 Jun 1;306(11):F1296-307. doi: 10.1152/ajprenal.00074.2014

    [ Epub 2014 Apr 9 ]


  • Logan RW, Robledo RF, Recla JM, Philip VM, Bubier JA, Jay JJ, Harwood C, Wilcox T, Gatti DM, Bult CJ, Churchill GA, Chesler EJ
    High-precision genetic mapping of behavioral traits in the diversity outbred mouse population
    Genes Brain Behav. 2013 Jun;12(4):424-37. doi: 10.1111/gbb.12029

    [ Epub 2013 Mar 20 ]

  • Noordmans GA, Caputo CR, Huang Y, Sheehan SM, Bulthuis M, Heeringa P, Hillebrands JL, van Goor H, Korstanje R
    Genetic analysis of mesangial matrix expansion in aging mice and identification of Far2 as a candidate gene
    J Am Soc Nephrol. 2013 Dec;24(12):1995-2001. doi: 10.1681/ASN.2012080838

    [ Epub 2013 Sep 5 ]

  • Strong R, Miller RA, Astle CM, Baur JA, de Cabo R, Fernandez E, Guo W, Javors M, Kirkland JL, Nelson JF, Sinclair DA, Teter B, Williams D, Zaveri N, Nadon NL, Harrison DE
    Evaluation of resveratrol, green tea extract, curcumin, oxaloacetic acid, and medium-chain triglyceride oil on life span of genetically heterogeneous mice
    J Gerontol A Biol Sci Med Sci. 2013 Jan;68(1):6-16. doi: 10.1093/gerona/gls070

    [ Epub 2012 Mar 26 ]

  • Yuan R, Flurkey K, Meng Q, Astle MC, Harrison DE
    Genetic regulation of life span, metabolism, and body weight in Pohn, a new wild-derived mouse strain
    J Gerontol A Biol Sci Med Sci. 2013 Jan;68(1):27-35. doi: 10.1093/gerona/gls104

    [ Epub 2012 May 8 ]


  • Begley DA, Krupke DM, Neuhauser SB, Richardson JE, Bult CJ, Eppig JT, Sundberg JP
    The Mouse Tumor Biology Database (MTB): a central electronic resource for locating and integrating mouse tumor pathology data
    Vet Pathol. 2012 Jan;49(1):218-23. doi: 10.1177/0300985810395726

    [ Epub 2011 Jan 31 ]

  • Flurkey K, Yuan R
    How the evolutionary theory of aging can guide us in the search for aging genes
    Aging (Albany NY). 2012 May;4(5):318-9

    [ No abstract available ]

  • Kavirayani AM, Sundberg JP, Foreman O
    Primary neoplasms of bones in mice: retrospective study and review of literature
    Vet Pathol. 2012 Jan;49(1):182-205. doi: 10.1177/0300985811398252

    [ Epub 2011 Feb 22 ]

  • Li Q, Berndt A, Guo H, Sundberg JP, Uitto J
    A novel animal model for pseudoxanthoma elasticum: the KK/HlJ mouse
    Am J Pathol. 2012 Oct;181(4):1190-6. doi: 10.1016/j.ajpath.2012.06.014

    [ Epub 2012 Jul 28 ]

  • Maddatu TP, Grubb SC, Bult CJ, Bogue MA
    Mouse Phenome Database (MPD)
    Nucleic Acids Res. 2012 Jan;40(Database issue):D887-94. doi: 10.1093/nar/gkr1061

    [ Epub 2011 Nov 18 ]

  • Murabito JM, Yuan R, Lunetta KL
    The search for longevity and healthy aging genes: insights from epidemiological studies and samples of long-lived individuals
    J Gerontol A Biol Sci Med Sci. 2012 May;67(5):470-9. doi: 10.1093/gerona/gls089
  • Schofield PN, Vogel P, Gkoutos GV, Sundberg JP
    Exploring the elephant: histopathology in high-throughput phenotyping of mutant mice
    Dis Model Mech. 2012 Jan;5(1):19-25. doi: 10.1242/dmm.008334

    [ Epub 2011 Oct 25 ]

  • Yuan R, Meng Q, Nautiyal J, Flurkey K, Tsaih SW, Krier R, Parker MG, Harrison DE, Paigen B
    Genetic coregulation of age of female sexual maturation and lifespan through circulating IGF1 among inbred mouse strains
    Proc Natl Acad Sci U S A. 2012 May 22;109(21):8224-9. doi: 10.1073/pnas.1121113109

    [ Epub 2012 May 7 ]


  • Lorenzo LP, Chen H, Shatynski KE, Clark S, Yuan R, Harrison DE, Yarowsky PJ, Williams MS
    Defective hematopoietic stem cell and lymphoid progenitor development in the Ts65Dn mouse model of Down syndrome: potential role of oxidative stress
    Antioxid Redox Signal. 2011 Oct 15;15(8):2083-94. doi: 10.1089/ars.2010.3798

    [ Epub 2011 Jun 15 ]

  • Miller RA, Harrison DE, Astle CM, Baur JA, Boyd AR, de Cabo R, Fernandez E, Flurkey K, Javors MA, Nelson JF, Orihuela CJ, Pletcher S, Sharp ZD, Sinclair D, Starnes JW, Wilkinson JE, Nadon NL, Strong R
    Rapamycin, but not resveratrol or simvastatin, extends life span of genetically heterogeneous mice
    J Gerontol A Biol Sci Med Sci. 2011 Feb;66(2):191-201. doi: 10.1093/gerona/glq178

    [ Epub 2010 Oct 25 ]

  • Schofield PN, Sundberg JP, Hoehndorf R, Gkoutos GV
    New approaches to the representation and analysis of phenotype knowledge in human diseases and their animal models
    Brief Funct Genomics. 2011 Sep;10(5):258-65. doi: 10.1093/bfgp/elr031
  • Sher RB, Cox GA, Mills KD, Sundberg JP
    Rhabdomyosarcomas in aging A/J mice
    PLoS One. 2011;6(8):e23498. doi: 10.1371/journal.pone.0023498

    [ Epub 2011 Aug 10 ]

  • Sinke AP, Caputo C, Tsaih SW, Yuan R, Ren D, Deen PM, Korstanje R
    Genetic analysis of mouse strains with variable serum sodium concentrations identifies the Nalcn sodium channel as a novel player in osmoregulation
    Physiol Genomics. 2011 Mar 16;43(5):265-70. doi: 10.1152/physiolgenomics.00188.2010

    [ Epub 2010 Dec 21 ]

  • Won J, Marín de Evsikova C, Smith RS, Hicks WL, Edwards MM, Longo-Guess C, Li T, Naggert JK, Nishina PM
    NPHP4 is necessary for normal photoreceptor ribbon synapse maintenance and outer segment formation, and for sperm development
    Hum Mol Genet. 2011 Feb 1;20(3):482-96. doi: 10.1093/hmg/ddq494

    [ Epub 2010 Nov 15 ]

  • Yuan R, Peters LL, Paigen B
    Mice as a mammalian model for research on the genetics of aging
    ILAR J. 2011;52(1):4-15


  • Flurkey K, Astle CM, Harrison DE
    Life extension by diet restriction and N-acetyl-L-cysteine in genetically heterogeneous mice
    J Gerontol A Biol Sci Med Sci. 2010 Dec;65(12):1275-84. doi: 10.1093/gerona/glq155

    [ Epub 2010 Sep 5 ]

  • Schofield PN, Gruenberger M, Sundberg JP
    Pathbase and the MPATH ontology. Community resources for mouse histopathology
    Vet Pathol. 2010 Nov;47(6):1016-20. doi: 10.1177/0300985810374845

    [ Epub 2010 Jun 29 ]

  • Sundberg JP, Schofield PN
    Commentary: mouse genetic nomenclature. Standardization of strain, gene, and protein symbols
    Vet Pathol. 2010 Nov;47(6):1100-4. doi: 10.1177/0300985810374837

    [ Epub 2010 Aug 4 ]


  • Yuan R, Tsaih SW, Petkova SB, Marin de Evsikova C, Xing S, Marion MA, Bogue MA, Mills KD, Peters LL, Bult CJ, Rosen CJ, Sundberg JP, Harrison DE, Churchill GA, Paigen B
    Aging in inbred strains of mice: study design and interim report on median lifespans and circulating IGF1 levels
    Aging Cell. 2009 Jun;8(3):277-87. doi: 10.1111/j.1474-9726.2009.00478.x

    [ Epub 2009 Apr 9 ]