by author Publications by date
2019
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Integration of heterogeneous functional genomics data in gerontology research to find genes and pathway underlying aging across speciesPLoS One. 2019 Apr 12;14(4):e0214523. doi: 10.1371/journal.pone.0214523 PMID: PMC6461221
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Mouse genome-wide association and systems genetics identifies Lhfp as a regulator of bone massPLoS Genet. 2019 May 1;15(5):e1008123. doi: 10.1371/journal.pgen.1008123. eCollection 2019 May. PMID: 31042701
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Quantitative evaluation of Ontology design patterns for combining pathology and anatomy ontologiesSci Rep. 2019 Mar 11;9(1):4025. doi:10.1038/s41598-019-40368-1. PMID: 30858527
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Sequencially inducible mouse models reveal that Npm1 mutation causes malignant transformation of Dnmt3a-mutant clonal hematopoiesisLeukemia. 2019 Jan 28. doi: 10.1038/s41375-018-0368-6. [Epub ahead of print]
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The renal molecular clock: broken by aging restored by exerciseAm J Physiol Renal Physiol. 2019 Nov 1;317(5):F1087-F1093. doi: 10.1152/ajprenal.00301.2019. Epub 2019 Aug 28.
2018
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A Multi-tissue full lifespan epigenetic clock for miceAging (Albany NY). 2018 Oct 21;10(10):2832-2854. doi: 10.18632/aging.101590. PMID:30348905
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FAR2 is Associated with Kidney Disease in Mice and HumansPhysiologenomics. 2018 Apr 13 doi:1152/physiolgenomics.00118.2017
2017
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MicroRNAs miR-203-3p, miR-664-3p and miR-708-5p are associated with median strain lifespan in miceSci Rep. 2017 Mar 17;7:44620. doi: 10.1038/srep44620
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Caenorhabditis elegans orthologs of human genes differentially expressed with age are enriched for determinants of longevityAging Cell, 2017 Aug;16(4):672-682. doi: 10.1111/acel.12595.
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Epistatic Networks Jointly Influence Phenotypes Related to Metabolic Disease and Gene Expression in Diversity Outbred MiceGenetics. 2017 Jun;206(2):621-639. doi: 10.1534/genetics.116.198051
[ PMCID: PMC5499176 ] 7 Citations
2016
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Accessing Data Resources in the Mouse Phenome Database for Genetic Analysis of Murine Life Span and Health SpanJ Gerontol A Biol Sci Med Sci. 2016 Feb;71(2):170-7. doi: 10.1093/gerona/glu223
[ Epub 2014 Dec 22 ]
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Loss of Kynurenine 3-Mono-oxygenase Causes ProteinuriaJ Am Soc Nephrol. 2016 Nov;27(11):3271-3277
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Changes in the expression of splicing factor transcripts and variations in alternative splicing are associated with lifespan in mice and humansAging Cell. 2016 Jun 30. doi: 10.1111/acel.12499
[Epub ahead of print]
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WORMHOLE: Novel Least Diverged Ortholog Prediction through Machine LearningPLoS Comput Biol. 2016 Nov 3;12(11):e1005182. doi: 10.1371/journal.pcbi.1005182.
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Progressive alterations in multipotent hematopoietic progenitors underlie lymphoid cell loss in agingJ Exp Med. 2016 Oct 17;213(11):2259-2267. Epub 2016 Oct 10.
2015
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Aging Research Using Mouse ModelsCurr Protoc Mouse Biol. 2015 Jun 1;5(2):95-133. doi: 10.1002/9780470942390.mo140195
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Suppressing NRIP1 inhibits growth of breast cancer cells in vitro and in vivoOncotarget. 2015 Nov 24;6(37):39714-24. doi: 10.18632/oncotarget.5356
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Collaborative Cross and Diversity Outbred data resources in the Mouse Phenome DatabaseMamm Genome. 2015 Oct;26(9-10):511-20. doi: 10.1007/s00335-015-9595-6
[ Epub 2015 Aug 19 ]
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A roadmap for the genetic analysis of renal agingAging Cell. 2015 Oct;14(5):725-33. doi: 10.1111/acel.12378
[ Epub 2015 Jul 29 ]
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The role of platelet-activating factor in mesangial pathophysiologyAm J Pathol. 2015 Apr;185(4):888-96. doi: 10.1016/j.ajpath.2014.11.025
[ Epub 2015 Feb 2 ]
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Genetic Regulation of Female Sexual Maturation and Longevity Through Circulating IGF1J Gerontol A Biol Sci Med Sci. 2015 Jul;70(7):817-26. doi: 10.1093/gerona/glu114
[ Epub 2014 Jul 28 ]
2014
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Quantitative trait locus mapping methods for diversity outbred miceG3 (Bethesda). 2014 Sep 18;4(9):1623-33. doi: 10.1534/g3.114.013748
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Alterations in thin filament length during postnatal skeletal muscle development and aging in miceFront Physiol. 2014 Sep 29;5:375. doi: 10.3389/fphys.2014.00375
[ eCollection 2014 ]
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Mouse phenome databaseNucleic Acids Res. 2014 Jan;42(Database issue):D825-34. doi: 10.1093/nar/gkt1159
[ Epub 2013 Nov 15 ]
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Identification of novel genes associated with renal tertiary lymphoid organ formation in aging micePLoS One. 2014 Mar 17;9(3):e91850. doi: 10.1371/journal.pone.0091850
[ eCollection 2014 ]
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Inbred mouse strains reveal biomarkers that are pro-longevity, antilongevity or role switchingAging Cell. 2014 Aug;13(4):729-38. doi: 10.1111/acel.12226
[ Epub 2014 May 23 ]
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Variation and genetic control of gene expression in primary immunocytes across inbred mouse strainsImmunological Genome Consortium. J Immunol. 2014 Nov 1;193(9):4485-96. doi: 10.4049/jimmunol.1401280
[ Epub 2014 Sep 29 ]
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Genetic analysis of intracapillary glomerular lipoprotein deposits in aging micePLoS One. 2014 Oct 29;9(10):e111308. doi: 10.1371/journal.pone.0111308
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Spontaneous voiding by mice reveals strain-specific lower urinary tract function to be a quantitative genetic traitAm J Physiol Renal Physiol. 2014 Jun 1;306(11):F1296-307. doi: 10.1152/ajprenal.00074.2014
[ Epub 2014 Apr 9 ]
2013
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High-precision genetic mapping of behavioral traits in the diversity outbred mouse populationGenes Brain Behav. 2013 Jun;12(4):424-37. doi: 10.1111/gbb.12029
[ Epub 2013 Mar 20 ]
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Genetic analysis of mesangial matrix expansion in aging mice and identification of Far2 as a candidate geneJ Am Soc Nephrol. 2013 Dec;24(12):1995-2001. doi: 10.1681/ASN.2012080838
[ Epub 2013 Sep 5 ]
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Evaluation of resveratrol, green tea extract, curcumin, oxaloacetic acid, and medium-chain triglyceride oil on life span of genetically heterogeneous miceJ Gerontol A Biol Sci Med Sci. 2013 Jan;68(1):6-16. doi: 10.1093/gerona/gls070
[ Epub 2012 Mar 26 ]
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Genetic regulation of life span, metabolism, and body weight in Pohn, a new wild-derived mouse strainJ Gerontol A Biol Sci Med Sci. 2013 Jan;68(1):27-35. doi: 10.1093/gerona/gls104
[ Epub 2012 May 8 ]
2012
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The Mouse Tumor Biology Database (MTB): a central electronic resource for locating and integrating mouse tumor pathology dataVet Pathol. 2012 Jan;49(1):218-23. doi: 10.1177/0300985810395726
[ Epub 2011 Jan 31 ]
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How the evolutionary theory of aging can guide us in the search for aging genesAging (Albany NY). 2012 May;4(5):318-9
[ No abstract available ]
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Primary neoplasms of bones in mice: retrospective study and review of literatureVet Pathol. 2012 Jan;49(1):182-205. doi: 10.1177/0300985811398252
[ Epub 2011 Feb 22 ]
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A novel animal model for pseudoxanthoma elasticum: the KK/HlJ mouseAm J Pathol. 2012 Oct;181(4):1190-6. doi: 10.1016/j.ajpath.2012.06.014
[ Epub 2012 Jul 28 ]
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Mouse Phenome Database (MPD)Nucleic Acids Res. 2012 Jan;40(Database issue):D887-94. doi: 10.1093/nar/gkr1061
[ Epub 2011 Nov 18 ]
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The search for longevity and healthy aging genes: insights from epidemiological studies and samples of long-lived individualsJ Gerontol A Biol Sci Med Sci. 2012 May;67(5):470-9. doi: 10.1093/gerona/gls089
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Exploring the elephant: histopathology in high-throughput phenotyping of mutant miceDis Model Mech. 2012 Jan;5(1):19-25. doi: 10.1242/dmm.008334
[ Epub 2011 Oct 25 ]
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Genetic coregulation of age of female sexual maturation and lifespan through circulating IGF1 among inbred mouse strainsProc Natl Acad Sci U S A. 2012 May 22;109(21):8224-9. doi: 10.1073/pnas.1121113109
[ Epub 2012 May 7 ]
2011
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Defective hematopoietic stem cell and lymphoid progenitor development in the Ts65Dn mouse model of Down syndrome: potential role of oxidative stressAntioxid Redox Signal. 2011 Oct 15;15(8):2083-94. doi: 10.1089/ars.2010.3798
[ Epub 2011 Jun 15 ]
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Rapamycin, but not resveratrol or simvastatin, extends life span of genetically heterogeneous miceJ Gerontol A Biol Sci Med Sci. 2011 Feb;66(2):191-201. doi: 10.1093/gerona/glq178
[ Epub 2010 Oct 25 ]
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New approaches to the representation and analysis of phenotype knowledge in human diseases and their animal modelsBrief Funct Genomics. 2011 Sep;10(5):258-65. doi: 10.1093/bfgp/elr031
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Rhabdomyosarcomas in aging A/J micePLoS One. 2011;6(8):e23498. doi: 10.1371/journal.pone.0023498
[ Epub 2011 Aug 10 ]
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Genetic analysis of mouse strains with variable serum sodium concentrations identifies the Nalcn sodium channel as a novel player in osmoregulationPhysiol Genomics. 2011 Mar 16;43(5):265-70. doi: 10.1152/physiolgenomics.00188.2010
[ Epub 2010 Dec 21 ]
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NPHP4 is necessary for normal photoreceptor ribbon synapse maintenance and outer segment formation, and for sperm developmentHum Mol Genet. 2011 Feb 1;20(3):482-96. doi: 10.1093/hmg/ddq494
[ Epub 2010 Nov 15 ]
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Mice as a mammalian model for research on the genetics of agingILAR J. 2011;52(1):4-15
2010
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Life extension by diet restriction and N-acetyl-L-cysteine in genetically heterogeneous miceJ Gerontol A Biol Sci Med Sci. 2010 Dec;65(12):1275-84. doi: 10.1093/gerona/glq155
[ Epub 2010 Sep 5 ]
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Pathbase and the MPATH ontology. Community resources for mouse histopathologyVet Pathol. 2010 Nov;47(6):1016-20. doi: 10.1177/0300985810374845
[ Epub 2010 Jun 29 ]
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Commentary: mouse genetic nomenclature. Standardization of strain, gene, and protein symbolsVet Pathol. 2010 Nov;47(6):1100-4. doi: 10.1177/0300985810374837
[ Epub 2010 Aug 4 ]
2009
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Aging in inbred strains of mice: study design and interim report on median lifespans and circulating IGF1 levelsAging Cell. 2009 Jun;8(3):277-87. doi: 10.1111/j.1474-9726.2009.00478.x
[ Epub 2009 Apr 9 ]