PUBLICATIONS

2012

HDL cholesterol and bone mineral density: Is there a genetic link?
Ackert-Bicknell CL.
Bone. 2012 Feb;50(2):525-33. PMCID: PMC3236254 [Available on 2013/2/1]

Genetic variation in TRPS1 may regulate hip geometry as well as bone mineral density.
Ackert-Bicknell CL, Demissie S, Tsaih SW, Beamer WG, Cupples LA, Paigen BJ, Hsu YH, Kiel DP, Karasik D.
Bone. 2012 May;50(5):1188-95. PMCID: PMC3322322 [Available on 2013/5/1]

The need for the mouse in osteoporosis genetics research.
Ackert-Bicknell CL, Hibbs MA.
BoneKEy. 2012. 50(2):525-533.

The Mouse Tumor Biology Database (MTB): A Central Electronic Resource for Locating and Integrating Mouse Tumor Pathology Data
Begley DA, Krupke DM, Neuhauser SB, Richardson JE, Bult CJ, Eppig JT, Sundberg JP.
Vet Pathol. 2012 Jan;49(1):218-23. PMCID: PMC3130112 [ Full Text ]

Diversity of spontaneous neoplasms in commonly used inbred strains of laboratory mice.
Begley D, Sundberg BA, Berndt A, Eppig JT, Schofield PN, Sundberg JP.
Hedrich HJ (ed.), The Laboratory Mouse, 2nd edition, Academic Press, London, 2012, pp. 411-427.

A Single-Nucleotide Polymorphism in the Abcc6 Gene Associates with Connective Tissue Mineralization in Mice Similar to Targeted Models for Pseudoxanthoma Elasticum.
Berndt A, Li Q, Potter CS, Liang Y, Silva KA, Kennedy V, Uitto J, Sundberg JP.
J Invest Dermatol. 2012 Sep 27.

How the evolutionary theory of aging can guide us in the search for aging genes.
Flurkey K, Yuan R.
Aging (Albany NY). 2012 May;4(5):318-9. PMCID: PMC3384432 [ Full Text ]

Primary neoplasms of bones in mice: retrospective study and review of literature.
Kavirayani AM, Sundberg JP, Foreman O.
Vet Pathol. 2012 Jan;49(1):182-205. PMCID: PMC3151475 [Available on 2013/1/1]

A Novel Animal Model for Pseudoxanthoma Elasticum: The KK/HlJ Mouse.
Li Q, Berndt A, Guo H, Sundberg JP, Uitto J.
Am J Pathol. 2012 Oct;181(4):1190-6. PMCID: PMC3463623 [Available on 2013/10/1]

Mouse Phenome Database (MPD).
Maddatu TP, Grubb SC, Bult CJ, Bogue MA.
Nucleic Acids Res. 2012 Jan;40(Database issue):D887-94. PMCID: PMC3245053 [ Full Text ]

The search for longevity and healthy aging genes: insights from epidemiological studies and samples of long-lived individuals.
Murabito JM, Yuan R, Lunetta KL.
J Gerontol A Biol Sci Med Sci. 2012 May;67(5):470-9. PMCID: PMC3326242 [Available on 2013/5/1]

Hammerhead ribozyme-mediated knockdown of mRNA for fibrotic growth factors: transforming growth factor-beta 1 and connective tissue growth factor.
Robinson PM, Blalock TD, Yuan R, Lewin AS, Schultz GS.
Methods Mol Biol. 2012;820:117-32.

Exploring the elephant: histopathology in high-throughput phenotyping of mutant mice.
Schofield PN, Vogel P, Gkoutos GV, Sundberg JP.
Dis Model Mech. 2012 Jan;5(1):19-25. PMCID: PMC3255539 [ Full Text ]

Development and Disease of the mouse muscular and Skeletal Systems.
Sher RB, Cox GA and Ackert-Bicknell C.
Hedrich HJ (ed.), The Laboratory Mouse, 2nd edition, Academic Press, London, 2012, pp. 209-239.

Necropsy methods.
Silva KA, Sundberg JP.
Hedrich HJ (ed.), The Laboratory Mouse, 2nd edition, Academic Press, London, 2012, pp. 781-811.

Early gene expression differences in inbred mouse strains with susceptibility to pulmonary adenomas.
Stearns TM, Cario CL, Savage HS, Sundberg JP, Paigen B, Berndt A.
Exp Mol Pathol. 2012 Sep 28.

Evaluation of Resveratrol, Green Tea Extract, Curcumin, Oxaloacetic Acid, and Medium-Chain Triglyceride Oil on Life Span of Genetically Heterogeneous Mice.
Strong R, Miller RA, Astle CM, Baur JA, de Cabo R, Fernandez E, Guo W, Javors M, Kirkland JL, Nelson JF, Sinclair DA, Teter B, Williams D, Zaveri N, Nadon NL, Harrison DE.
J Gerontol A Biol Sci Med Sci. 2012 Mar 26.

Training mouse pathologists: ten years of workshops on the Pathology of Mouse Models of Human Disease.
Sundberg JP, Hogenesch H, Nikitin AY, Treuting PM, Ward JM.
Toxicol Pathol. 2012 Jul;40(5):823-5.

High-resolution genetic mapping using the Mouse Diversity outbred population.
Svenson KL, Gatti DM, Valdar W, Welsh CE, Cheng R, Chesler EJ, Palmer AA, McMillan L, Churchill GA.
Genetics. 2012 Feb;190(2):437-47. PMCID: PMC3276626 [Available on 2013/2/1]

Rapamycin slows aging in mice.
Wilkinson JE, Burmeister L, Brooks SV, Chan CC, Friedline S, Harrison DE, Hejtmancik JF, Nadon N, Strong R, Wood LK, Woodward MA, Miller RA.
Aging Cell. 2012 Aug;11(4):675-82. PMCID: PMC3434687 [ Full Text ]

Aging Kit mutant mice develop cardiomyopathy.
Ye L, Zhang EY, Xiong Q, Astle CM, Zhang P, Li Q, From AH, Harrison DE, Zhang JJ.
PLoS One. 2012;7(3):e33407. PMCID: PMC3302804 [ Full Text ]

Genetic Regulation of Life Span, Metabolism, and Body Weight in Pohn, a New Wild-Derived Mouse Strain.
Yuan R, Flurkey K, Meng Q, Astle MC, Harrison DE.
J Gerontol A Biol Sci Med Sci. 2012 May 8.

Genetic coregulation of age of female sexual maturation and lifespan through circulating IGF1 among inbred mouse strains.
Yuan R, Meng Q, Nautiyal J, Flurkey K, Tsaih SW, Krier R, Parker MG, Harrison DE, Paigen B.
Proc Natl Acad Sci U S A. 2012 May 22;109(21):8224-9. PMCID: PMC3361401 [Available on 2012/11/22]

Fetal myocardium in the kidney capsule: an in vivo model of repopulation of myocytes by bone marrow cells.
Zhang EY, Xiong Q, Ye L, Suntharalingam P, Wang X, Astle CM, Zhang J, Harrison DE.
PLoS One. 2012;7(2):e31099. PMCID: PMC3285614 [ Full Text ]

2011

BMD regulation on mouse distal chromosome 1, candidate genes, and response to ovariectomy or dietary fat
Beamer WG, Shultz KL, Coombs HF 3rd, DeMambro VE, Reinholdt LG, Ackert-Bicknell CL, Canalis E, Rosen CJ, Donahue LR.
J Bone Miner Res. 2011 Jan;26(1):88-99. PMCID: PMC3179313 [ Full Text ]

Identification of fat4 and tsc22d1 as novel candidate genes for spontaneous pulmonary adenomas.
Berndt A, Cario CL, Silva KA, Kennedy VE, Harrison DE, Paigen B, Sundberg JP.
Cancer Res. 2011 Sep 1;71(17):5779-91. PMCID: PMC3165088 [ Full Text ]

Defective hematopoietic stem cell and lymphoid progenitor development in the Ts65Dn mouse model of Down syndrome: potential role of oxidative stress
Lorenzo LP, Chen H, Shatynski KE, Clark S, Yuan R, Harrison DE, Yarowsky PJ, Williams MS.
Antioxid Redox Signal. 2011 Oct 15;15(8):2083-94. PMCID: PMC3166202

Rapamycin, but not resveratrol or simvastatin, extends life span of genetically heterogeneous mice.
Miller RA, Harrison DE, Astle CM, Baur JA, Boyd AR, de Cabo R, Fernandez E, Flurkey K, Javors MA, Nelson JF, Orihuela CJ, Pletcher S, Sharp ZD, Sinclair D, Starnes JW, Wilkinson JE, Nadon NL, Strong R.
J Gerontol A Biol Sci Med Sci. 2011 Feb;66(2):191-201. PMCID: PMC3021372 [ Full Text ]

Genetic analysis in the Collaborative Cross breeding population.
Philip VM, Sokoloff G, Ackert-Bicknell CL, Striz M, Branstetter L, Beckmann MA, Spence JS, Jackson BL, Galloway LD, Barker P, Wymore AM, Hunsicker PR, Durtschi DC, Shaw GS, Shinpock S, Manly KF, Miller DR, Donohue KD, Culiat CT, Churchill GA, Lariviere WR, Palmer AA, O’Hara BF, Voy BH, Chesler EJ.
Genome Res. 2011 Aug;21(8):1223-38. PMCID: PMC3149490 [ Full Text ]

New approaches to the representation and analysis of phenotype knowledge in human diseases and their animal models
Schofield PN, Sundberg JP, Hoehndorf R, Gkoutos GV.
Brief Funct Genomics. 2011 Sep;10(5):258-65. PMCID: PMC3189694 [ Full Text ]

New approaches to the representation and analysis of phenotype knowledge in human diseases and their animal models.
Schofield PN, Sundberg JP, Hoehndorf R, Gkoutos GV.
Brief Funct Genomics. 2011 Sep;10(5):258-65. PMCID: PMC3189694 [ Full Text ]

Rhabdomyosarcomas in aging A/J mice
Sher RB, Cox GA, Mills KD, Sundberg JP.
PLoS One. 2011;6(8):e23498. PMCID: PMC3154500 [ Full Text ]

Genetic analysis of mouse strains with variable serum sodium concentrations identifies the Nalcn sodium channel as a novel player in osmoregulation.
Sinke AP, Caputo C, Tsaih SW, Yuan R, Ren D, Deen PM, Korstanje R.
Physiol Genomics. (2011) 43(5):265-70. PMCID: PMC3068516 [ Full Text ] [ Datasets ]

The mouse as a model for understanding chronic diseases of aging: the histopathologic basis of aging in inbred mice
Sundberg JP, Berndt A, Sundberg BA, Silva KA, Kennedy V, Bronson R, Yuan R, Paigen B, Harrison D, Schofield PN.
Pathobiology of Aging & Age-related Diseases (2011) 1: 7179 – DOI: 10.3402/pba.v1i0.7179
[ Full Text ] [ Datasets 1 ] [ Datasets 2 ]

NPHP4 is necessary for normal photoreceptor ribbon synapse maintenance and outer segment formation, and for sperm development.
Won J, Marín de Evsikova C, Smith RS, Hicks WL, Edwards MM, Longo-Guess C, Li T, Naggert JK, Nishina PM.
Hum Mol Genet. (2011) 20(3):482-96. PMCID: PMC3016909 [ Full Text ]

Mice as a mammalian model for research on the genetics of aging
Yuan R, Peters LL, Paigen B.
ILAR J. (2011) 52(1):4-15. PMCID: PMC3074346  [ Full Text ]

2010

Mouse BMD quantitative trait loci show improved concordance with human genome-wide association loci when recalculated on a new, common mouse genetic map
Ackert-Bicknell CL, Karasik D, Li Q, Smith RV, Hsu YH, Churchill GA, Paigen BJ, Tsaih SW.
J Bone Miner Res. (2010) 25(8):1808-20. PMCID: PMC3153351 [ Full Text ]

A novel spontaneous mutation of Irs1 in mice results in hyperinsulinemia, reduced growth, low bone mass and impaired adipogenesis
DeMambro VE, Kawai M, Clemens TL, Fulzele K, Maynard JA, Marín de Evsikova C, Johnson KR, Canalis E, Beamer WG, Rosen CJ, Donahue LR.
J Endocrinol. (2010) 204(3):241-53. PMCID: PMC3033737 [ Full Text ]

Photoreceptor degeneration, azoospermia, leukoencephalopathy, and abnormal RPE cell function in mice expressing an early stop mutation in CLCN2.
Edwards MM, Marín de Evsikova C, Collin GB, Gifford E, Wu J, Hicks WL, Whiting C, Varvel NH, Maphis N, Lamb BT, Naggert JK, Nishina PM, Peachey NS.
Invest Ophthalmol Vis Sci. (2010) 51(6):3264-72. PMCID: PMC2891478 [ Full Text ]

Hematopoietic Stem Cell Aging
Ertl, RP, Harrison DE.
Regenerative Medicine. (2010) Chapter 38. Scott EW, Fisher RC, eds. Jones Bartlett.

Life extension by diet restriction and N-acetyl-L-cysteine in genetically heterogeneous mice
Flurkey K, Astle CM, Harrison DE.
J Gerontol A Biol Sci Med Sci. (2010) 65(12):1275-84. PMCID: PMC2990268 [ Full Text ]

Reproductive ageing: Of worms and women
Flurkey K, Harrison DE.
Nature. (2010) 468(7322):386-7.

Functional genomics complements quantitative genetics in identifying disease-gene associations
Guan Y, Ackert-Bicknell CL, Kell B, Troyanskaya OG, Hibbs MA.
PLoS Comput Biol. 2010 Nov 11;6(11):e1000991. PMCID: PMC2978695 [ Full Text ]

Identification of genetic determinants of IGF-1 levels and longevity among mouse inbred strains
Leduc MS, Hageman RS, Meng Q, Verdugo RA, Tsaih SW, Churchill GA, Paigen B, Yuan R.
Aging Cell. (2010) 823-36. doi: 10.1111/j.1474-9726.2010.00612.x. PMCID: PMC3025299 [ Full Text ]
[ Datasets ]

Regulation of selenoproteins and methionine sulfoxide reductases A and B1 by age, calorie restriction, and dietary selenium in mice.
Novoselov SV, Kim HY, Hua D, Lee BC, Astle CM, Harrison DE, Friguet B, Moustafa ME, Carlson BA, Hatfield DL, Gladyshev VN.
Antioxid Redox Signal. (2010) 12(7):829-38. PMCID: PMC2864656 [ Full Text ]

Phenotype ontologies for mouse and man: bridging the semantic gap
Schofield PN, Gkoutos GV, Gruenberger M, Sundberg JP, Hancock JM.
Dis Model Mech. (2010) 3(5-6):281-9. PMCID: PMC2860848 [ Full Text ]

Pathbase and the MPATH ontology. Community resources for mouse histopathology
Schofield PN, Gruenberger M, Sundberg JP.
Vet Pathol. (2010) 47(6):1016-20. PMCID: PMC3038412 [ Full Text ]

Commentary: mouse genetic nomenclature. Standardization of strain, gene, and protein symbols
Sundberg JP, Schofield PN.
Vet Pathol. (2010) 47(6):1100-4. PMCID: PMC3039125 [ Full Text ]

Genetic analysis of albuminuria in aging mice and concordance with loci for human diabetic nephropathy found in a genome-wide association scan
Tsaih SW, Pezzolesi MG, Yuan R, Warram JH, Krolewski AS, Korstanje R.
Kidney Int. (2010) 77(3):201-10. PMCID: PMC2807478 [ Full Text ] [ Datasets ]

2009

Neuroendocrine inhibition of glucose production and resistance to cancer in dwarf mice
Alderman JM, Flurkey K, Brooks NL, Naik SB, Gutierrez JM, Srinivas U, Ziara KB, Jing L, Boysen G, Bronson R, Klebanov S, Chen X, Swenberg JA, Stridsberg M, Parker CE, Harrison DE, Combs TP.
Exp Gerontol (2009) 44(1-2): 26-33. PMCID: PMC2872123 [ Full Text ]

Gene expression during the oocyte-to-embryo transition in mammals
Evsikov AV, Marín de Evsikova C.
Molecular Reproduction and Development (2009) 76:805-818. PMCID: PMC2974443 [ Full Text ]

Evolutionary origin and phylogenetic analysis of the novel oocyte-specific eukaryotic translation initiation factor 4E in Tetrapoda
Evsikov AV, Marín de Evsikova C.
Dev Genes Evol. (2009) Feb;219(2):111-8. PMCID: PMC2863988 [ Full Text ]

Mouse phenome database
Grubb SC, Maddatu TP, Bult CJ, Bogue MA.
Nucleic Acids Res. (2009) 37(Database issue): D720-30. PMCID: PMC2686531 [ Full Text ]

Rapamycin fed late in life extends lifespan in genetically heterogeneous mice
Harrison DE, Strong R, Sharp ZD, Nelson JF, Astle CM, Flurkey K, Nadon NL, Wilkinson JE, Frenkel K, Carter CS, Pahor M, Javors MA, Fernandez E, Miller RA.
Nature (2009) 460(7253): 392-5. PMCID: PMC2786175 [ Full Text ]

Transcriptome analysis reveals an unexpected role of a collagen tyrosine kinase receptor gene as a regulator of ovarian function
Matsumura K, Kano K, Marín de Evsikova C, Young J, Nishina PM, Naggert JK, Naito K.
Physiological Genomics (2009) 39:120-129. PMCID: PMC2765065 [ Full Text ]

One medicine, one pathology, and the one health concept
Sundberg JP, Schofield PN.
J Am Vet Med Assoc (2009) 234(12): 1530-1.

Age, experience and genetic background influence treadmill walking in mice
Wooley CM, Xing S, Burgess RW, Cox GA, Seburn KL.
Physiol Behav (2009) 96(2): 350-61. PMCID: PMC2759980 [Full Text ]

Genetic influence on electrocardiogram time intervals and heart rate in aging mice
Xing S, Tsaih SW, Yuan R, Svenson KL, Jorgenson LM, So M, Paigen BJ, Korstanje R.
Am J Physiol Heart Circ Physiol (2009) 296(6): H1907-13. PMCID: PMC2716104 [ Full Text ] [ Datasets ]

Aging in inbred strains of mice: study design and interim report on median lifespans and circulating IGF1 levels
Yuan R, Tsaih SW, Petkova SB, de Evsikova CM, Xing S, Marion MA, Bogue MA, Mills KD, Peters LL, Bult CJ, Rosen CJ, Sundberg JP, Harrison DE, Churchill GA, Paigen B.
Aging Cell (2009) 8(3): 277-87. PMCID: PMC2768517 [ Full Text ] [ Datasets 1 ] [ Datasets 2 ]

2008

Effects of dietary restriction on hematopoietic stem-cell aging are genetically regulated
Ertl RP, Chen J, Astle CM, Duffy TM, Harrison DE.
Blood (2008) 111(3): 1709-16. PMCID: PMC2214738 [ Full Text ]

A novel dwarfism with gonadal dysfunction due to loss-of-function allele of the collagen receptor gene, Ddr2, in the mouse
Kano K, Marin de Evsikova C, Young J, Wnek C, Maddatu TP, Nishina PM, Naggert JK.
Mol Endocrinol (2008) 22(8): 1866-80. PMCID: PMC2505327 [ Full Text ]

The mouse tumor biology database
Krupke D, Begley D, Sundberg J, Bult C, Eppig J.
Nature Rev Cancer (2008) 8:459-465. PMCID: PMC2574871 [ Full Text ]

Genetic influence on immune phenotype revealed strain-specific variations in peripheral blood lineages
Petkova SB, Yuan R, Tsaih SW, Schott W, Roopenian DC, Paigen B.
Physiol Genomics (2008) 34(3): 304-14. PMCID: PMC2519960 [ Full Text ] [ Datasets ]

Nordihydroguaiaretic acid and aspirin increase lifespan of genetically heterogeneous male mice
Strong R, Miller RA, Astle CM, Floyd RA, Flurkey K, Hensley KL, Javors MA, Leeuwenburgh C, Nelson JF, Ongini E, Nadon NL, Warner HR, Harrison DE.
Aging Cell (2008) 7(5): 641-50. PMCID: PMC2695675 [ Full Text ]

Integrating mouse anatomy and pathology ontologies into a phenotyping database: tools for data capture and training
Sundberg JP, Sundberg BA, Schofield P.
Mamm Genome (2008) 19(6): 413-9. PMCID: PMC2844541 [ Full Text ]

2007

Low utilization of circulating glucose after food withdrawal in Snell dwarf mice.
Brooks NL, Trent CM, Raetzsch CF, Flurkey K, Boysen G, Perfetti MT, Jeong YC, Klebanov S, Patel KB, Khodush VR, Kupper LL, Carling D, Swenberg JA, Harrison DE, Combs TP.
J Biol Chem. (2007) 282(48):35069-77. [ Full Text ]

PohnB6F1: a cross of wild and domestic mice that is a new model of extended female reproductive life span
Flurkey K, Brandvain Y, Klebanov S, Austad SN, Miller RA, Yuan R, Harrison DE.
J Gerontol A Biol Sci Med Sci (2007) 62(11): 1187-98.

An Aging Interventions Testing Program: study design and interim report
Miller RA, Harrison DE, Astle CM, Floyd RA, Flurkey K, Hensley KL, Javors MA, Leeuwenburgh C, Nelson JF, Ongini E, Nadon NL, Warner HR, Strong R.
Aging Cell (2007) 6(4): 565-75. [ Full Text ]

2006

Pituitary removal in adult mice increases life span.
Powers RW 3rd, Harrison DE, Flurkey K.
Mech Ageing Dev. (2006) 127(8):658-9.

Altered growth characteristics of skin fibroblasts from wild-derived mice, and genetic loci regulating fibroblast clone size
Yuan R, Flurkey K, Van Aelst-Bouma R, Zhang W, King B, Austad S, Miller RA, Harrison DE.
Aging Cell (2006) 5(3): 203-12. [ Full Text ]