Core Leader: Ron Korstanje
The Development Core seeks to expand the research focus on aging, healthspan and age-related diseases at JAX through a robust Research Development Core by actively supporting and mentoring both new and established investigators who are developing new programs in the field of aging biology. Investigators are directly supported through a process of pilot project funding. In addition, the Jackson Aging Center (JAC) provides access to aged animals and samples collected from aged animals to support pilot project awardees and other qualified investigators. JAC investigators serve as mentors to promote career development for new investigators in the field of aging biology by providing support for organizing and hosting aging-related courses, seminars, and workshops at our Bar Harbor (Maine) and Farmington (Connecticut) campuses, and collaborating institutes. The below are pilot project awardees since 2015.
2018 Pilot Project Grantees:
Danitza Nebor, Ph.D. The Jackson Laboratory
Investigate whether decreasing of mTORC1 activity would increase the expression of the mouse bh1
Matt Kaeberlein, Ph.D. University of Washington
Examine and compare the effects of in-chow of 42mg/kg/day of rapamycin (42 ppm eRAPA) for 8 weeks (~2 months) on age-associated periodontal disease in wild-type C57BL/6 mice at 20 months of age.
Steven Gygi, Ph.D., Harvard University
The aged mouse proteome
Margarita Meer, Ph.D., Harvard University
Development of a blood-based DNA methylation clock in mice
Berenice Benayoun, Ph.D., University of Southern California
Sex dimorphism in aging macrophages
Danielle Bruns Ph.D./Emily Schmitt, Ph.D., University of Wyoming
Linking Cardiac Aging with Biological Clock Activity
Aby Buchwalter, Ph.D., University of California San Francisco
Quantify nucleor size as a proxy for nucleolar activity over age in tissue sections at 6, 12 and 18 months
Shohana Yakar, Ph.D. NYU
Test the effect of Methylene Blue on bone quality during Aging
Samual Beck, Ph.D., Mount Desert Island Biological Laboratory
CpG islands and chromatin architecture changes during aging
Giovanni Mann, Ph.D., King’s College London
Impact of ageing on endothelial cell trafficking of intermediate conductance Ca2+ activated potassium channels
2017 Pilot Project Grantees:
Muneer Hasham, Ph.D.,The Jackson Laboratory
Determining the genetic variations that impact the age-related B-cell immune response.
Duygu Ucar, Ph.D., The Jackson Laboratory
Epigenomic disruption of immune cell functions with aging in CC founder strains
Catherine Kaczorowski, Ph.D.,The Jackson Laboratory
Systems Genetics of Normal Aging and Alzheimer's Disease.
Ewelina Bolcun-filas, Ph.D.,The Jackson Laboratory
Genetics and Genomics of the Ovarian Reserve and Female Fertility
Olga Anczukow, Ph.D.,The Jackson Laboratory
Identifying age-related changes in splicing regulation in the mammary gland
John Fryer, Ph.D., Mayo Clinic
Use single-cell RNAseq technology to determine the cellular response in all cell types in the aging brain.
2015/2016 Pilot Project Grantees:
Brett Kaufman, Ph.D., University of Pittsburg
Genetic Control of Mitochondrial DNA content with Aging
Gareth Howell, Ph.D., The Jackson Laboratory
Investigating the role of APOE in age-related neurovascular unit decline and neuroinflammation.