Catherine Kaczorowski, Ph.D.
Associate Professor, The Jackson Laboratory
My research focus is to identify early causative events that underlie cognitive deficits associated with ‘normal’ aging and Alzheimer’s disease. Using multidisciplinary approaches that combine systems genetics with innovative high resolution and high throughput membrane proteomics, viral-based gene transduction approaches, behavioral assays, in vitro brain slice electrophysiology and in vivo electrophysiological recordings in freely behaving mice, my research seeks to identify and understand how genetic factors and misregulated membrane proteins in the hippocampus of aging and AD mouse models alter hippocampal neuron excitability, functional connectivity of hippocampal neural networks, and memory.
George A Kuchel, M.D., FRCP, AGSF
George A. Kuchel, MD is Professor, Chief of Geriatrics and Director of the UConn Center on Aging at the University of Connecticut in Farmington CT where he also holds the Travelers Chair in Geriatrics and Gerontology. Dr Kuchel’s research has focused on translational approaches to common geriatric syndromes and chronic diseases, with a particular emphasis on the development of geroscience-guided interventions into aging- and disease-related declines in immune responses to vaccines, mobility, cognition and bladder control. Among other funded ongoing projects, Dr Kuchel is multiple PI of the NIA Translational Geroscience Network and member of the leadership team for the TAME (Targeting Aging with Metformin) clinical trial.
George Sutphin, Ph.D.
Assistant Professor, Molecular & Cellular Biology, University of Arizona
The goal of Dr. Sutphin's research is to identify and characterize novel molecular mechanisms of aging. The Sutphin lab employs a comparative systems genetics pipeline that leverages the unique strengths of three model systems—humans, mice, and roundworms—to identify novel genetic and environmental factors that contribute to aging across animal species that can be beneficially targeted to extend healthy lifespan and treat age-associated disease. Our current focus is on three major areas: (1) developing automated methods to increase throughput and reproducibility of survival analysis in roundworms, (2) identifying the mechanisms underlying lifespan extension from interventions targeting tryptophan-kynurenine metabolism in mice and roundworms, and (3) understanding how animals respond when challenged with multiple, simultaneous forms of cellular stress.
George Weinstock, Ph.D.
Professor, Director of Microbial Genomics, The Jackson Laboratory
The Weinstock laboratory studies the role of the microbiome in aging. In one human study, the inreased viral load in elderly versus young is being correlatd with host responses as a contributor to the "inflammaging" model for aging. In mouse studies, diversity outbred mice cohorts of various ages are used to correlate host phenotypes with microbiome composition, map host genes that influence quantitatve traits and the microbiome, and test causality of microbiome composition for host traits.
External Advisory Board
Morgan Levine, PhD
Assistant Professor, Pathology and Epidemiology
Yale School of Medicine
James Nelson, PhD
Professor, Department of Cellular and Integrative Physiology
Barshop Institute for Longevity and Aging Studies
University of Texas Health Science Center at San Antonio
Richard Sprott, PhD
Former Executive Director
The Ellison Medical Foundation
Ashley E. Webb, PhD
Assistant Professor, Department of Molecular Biology, Cell Biology and Biochemistry
Matt Kaeberlein, PhD
Associate Professor, Department of Pathology
University of Washington